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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 125317-39-7 |
| 是否进口 | 否 |
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Fields of Application :
Vinorelbine (Navelbine) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
| CAS Number: | 125317-39-7 |
| Purity: |
99% |
| Molecular Weight: | 778.93 |
| Molecular Formula: | C45H54N4O8 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | N/A |
| Chemical Name: | Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)- |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Vinorelbine tartrate is the ditartrate salt of a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) with antineoplastic activity. Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle Formation and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor activity, whereas inhibition of axonal microtubules seems to correlate with vinorelbine's neurotoxicity. Compared to related vinca alkaloids, vinorelbine is more selective against mitotic than axonal microtubules in vitro, which may account For its decreased neurotoxicity. This agent is also a radiation-sensitizing agent. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) For the detailed information about the solubility of Vinorelbine Ditartrate in water, the solubility of Vinorelbine Ditartrate in DMSO, the solubility of Vinorelbine Ditartrate in PBS buffer, the animal experiment（test） of Vinorelbine Ditartrate, the in vivo,in vitro and clinical trial test of Vinorelbine Ditartrate, the cell experiment（test） of Vinorelbine Ditartrate, the IC50, EC50 and Affinity of Vinorelbine Ditartrate.
References:
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