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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 133550-30-8 |
| 是否进口 | 否 |
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Fields of Application :
AG-490 (Tyrphostin B42) is an inhibitor of EGFR, ErbB2 and JAK2 with IC50 of 0.1 μM, 13.5 μM, and ~10 μM, respectively.
| CAS Number: | 133550-30-8 |
| Purity: | >98% |
| Molecular Weight: | 294.3 |
| Molecular Formula: | C17H14N2O3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | AG-490,AG 490 |
| Chemical Name: | (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Tyrphostin AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. The hematopoietic cancer c-Kit+, Jak-2+ and non hematopoietic tumors c-Kit+, HER-2+, JAK-2+ can be inhibited by the chemosensitizing agent AG490 causing programmed cell death. For the detailed information about the solubility of AG 490 in water, the solubility of AG 490 in DMSO, the solubility of AG 490 in PBS buffer, the animal experiment（test） of AG 490,the in vivo,in vitro and clinical trial test of AG 490,the cell experiment（test） of AG 490,the IC50, EC50 and Affinity of AG 490.
References:
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