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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 722544-51-6 |
| 是否进口 | 否 |
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Fields of Application :
AZD1152-HQPA (Barasertib) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM.
| CAS Number: | 722544-51-6 |
| Purity: | >98% |
| Molecular Weight: | 507.56 |
| Molecular Formula: | C26H30FN7O3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | AZD1152, AZD-1152 |
| Chemical Name: | 2-(5-(7-(3-(ethyl(2-hydroxyethyl)amino)propoxy)quinazolin-4-ylamino)-1H-pyrazol-3-yl)-N-(3-fluorophenyl)acetamide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Description of AZD-1152HQPA: AZD-1152HQPA is an active metabolite of Barasertib (AZD-1152), which is a novel acetanilide-substituted pyrazole-aminoquinazoline prodrug that is converted rapidly to the active drug AZD-1152 hydroxy-QPA (AZD1152-HQPA) in human plasma. AZD1152-HQPA is a specific inhibitor of the enzymatic activity of Aurora kinase, with selectivity For Aurora B (IC50 of 0.37 nM versus 1368 nM For Aurora B and A kinases, respectively); the inhibitor had even less activity against a panel of greater than 50 other serine-threonine and tyrosine kinases including FLT3, JAK2, and Abl. Preliminary studies showed that AZD-1152 was active against a variety of solid tumors including colon, breast, and lung cancers. For the detailed information about the solubility of Barasertib (AZD1152-HQPA) in water, the solubility of Barasertib (AZD1152-HQPA) in DMSO, the solubility of Barasertib (AZD1152-HQPA) in PBS buffer, the animal experiment（test） of Barasertib (AZD1152-HQPA),the in vivo,in vitro and clinical trial test of Barasertib (AZD1152-HQPA),the cell experiment（test） of Barasertib (AZD1152-HQPA),the IC50, EC50 and Affinity of Barasertib (AZD1152-HQPA).
References:
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