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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 571170-77-9 |
| 是否进口 | 否 |
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Fields of Application :
MK 0524 is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 μM for the DP1 and DP2 receptors, respectively.
| CAS Number: | 571170-77-9 |
| Purity: | 99.85% |
| Molecular Weight: | 435.901 |
| Molecular Formula: | C21H19ClFNO4S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | mk0524,Laropiprant,MK-0524 |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
MK 0524 is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 μM For the DP1 and DP2 receptors, respectively. It inhibits PGD2-induced accumulation of cAMP in both washed platelets and platelet-rich plasma with IC50 values of 0.09 and 4.0 nM, respectively. In a sheep model of allergic rhinitis, 0.1 mg/kg MK 0524 completely blocked PGD2-induced nasal congestion. At a dose of 4 mg/kg, MK 0524 suppressed a nicotinic acid-induced vasodilatory response by 80% in a murine model of flushing, an undesirable side-effect of niacin treatment For dyslipidemia. For the detailed information about the solubility of Laropiprant (MK-0524) in water, the solubility of Laropiprant (MK-0524) in DMSO, the solubility of Laropiprant (MK-0524) in PBS buffer, the animal experiment（test） of Laropiprant (MK-0524),the in vivo,in vitro and clinical trial test of Laropiprant (MK-0524),the cell experiment（test） of Laropiprant (MK-0524),the IC50, EC50 and Affinity of Laropiprant (MK-0524).
References:
CS(=O)(=O)C1=C2C(=CC(=C1)F)C3=C(N2CC4=CC=C(C=C4)Cl)[C@H](CC3)CC(=O)O
