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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 163451-81-8 |
| 是否进口 | 否 |
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Fields of Application :
Teriflunomide: Teriflunomide, aslo know as A77 1726 (trade name Aubagio, marketed by Sanofi) is the active metabolite of leflunomide.
| CAS Number: | 163451-81-8 |
| Purity: | >98% |
| Molecular Weight: | 270.21 |
| Molecular Formula: | C12H9F3N2O2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | A-771726,A 771726,A771726 |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Description of Teriflunomide: Teriflunomide, aslo know as A77 1726 (trade name Aubagio, marketed by Sanofi) is the active metabolite of leflunomide. Teriflunomide is an immunomodulatory drug inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase. It is uncertain whether this explains its effect on MS lesions. Teriflunomide inhibits rapidly dividing cells, including activated T cells, which are thought to drive the disease process in MS. Teriflunomide may decrease the risk of infections compared to chemotherapy-like drugs because of its more-limited effects on the immune system. It has been found that teriflunomide blocks the transcription factor NF-κB. It also inhibits tyrosine kinase enzymes, but only in high doses not clinically used. The drug was approved by the FDA on September 13, 2012. For the detailed information about the solubility of Teriflunomide in water, the solubility of Teriflunomide in DMSO, the solubility of Teriflunomide in PBS buffer, the animal experiment（test） of Teriflunomide, the in vivo,in vitro and clinical trial test of Teriflunomide, the cell experiment（test） of Teriflunomide, the IC50, EC50 and Affinity of Teriflunomide .
References:
C(NC1=CC=C(C(F)(F)F)C=C1)(=O)/C(/C#N)=C(\O)/C
