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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1260251-31-7 |
| 是否进口 | 否 |
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Fields of Application :
Birinapant (TL32711) is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM, less potent to XIAP.
| CAS Number: | 1260251-31-7 |
| Purity: | >98% |
| Molecular Weight: | 806.94 |
| Molecular Formula: | C42H56F2N8O6 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | TL-32711; TL32711; TL 32711. Birinapant |
| Chemical Name: | (2S,2'S)-N,N'-((2S,2'S)-((3S,3'S,5R,5'R)-5,5'-((6,6'-difluoro-1H,1'H-[2,2'-biindole]-3,3'-diyl)bis(methylene))bis(3-hydroxypyrrolidine-5,1-diyl))bis(1-oxobutane-2,1-diyl))bis(2-(methylamino)propanamide) |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, TL32711 binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains.For the detailed information of Birinapant (TL32711), the solubility of Birinapant (TL32711) in water, the solubility of Birinapant (TL32711) in DMSO, the solubility of Birinapant (TL32711) in PBS buffer, the animal experiment (test) of Birinapant (TL32711), the cell expriment (test) of Birinapant (TL32711), the in vivo, in vitro and clinical trial test of Birinapant (TL32711), the EC50, IC50,and Affinity of Birinapant (TL32711).
References:
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