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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1355326-35-0 |
| 是否进口 | 否 |
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Fields of Application :
AGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM.
| CAS Number: | 1355326-35-0 |
| Purity: | >98% |
| Molecular Weight: | 462.56 |
| Molecular Formula: | C27H31FN4O2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | IDH-C35,AGI5198,AGI 5196 |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
AGI-5198(IDH C35) is a novel R132H-IDH1 inhibitor, identified through a high-throughput screen blocked R132H-IDH1 activity in a dose-dependent manner. IC50 Value: The ability of the mutant enzyme (mIDH1) to produce R-2-hydroxyglutarate (R-2HG). The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered metabolism of cancer cells for cancer therapy. Isocitrate dehydrogenase 1 (IDH1) is one potential drug target, which is mutated in multiple human cancers For the detailed information of AGI-5198, the solubility of AGI-5198 in water, the solubility of AGI-5198 in DMSO, the solubility of AGI-5198 in PBS buffer, the animal experiment (test) of AGI-5198, the cell expriment (test) of AGI-5198, the in vivo, in vitro and clinical trial test of AGI-5198, the EC50, IC50,and Affinity of AGI-5198.
References:
CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C
