|
| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 950769-58-1 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | 奎扎替尼 | 英文名 | Quizartinib |
|---|---|---|---|
| CAS号 | 950769-58-1 | 分子量 | 560.667 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | N/A |
| 分子式 | C29H32N6O4S | 熔点 | N/A |
| MSDS | N/A | 闪点 | N/A |
Quizartinib (AC220) 是一种有效的 Flt3 酪氨酸激酶抑制剂，Kd值为1.6±0.7 nM。
Fields of Application :
Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Phase 1/2.
| CAS Number: | 950769-58-1 |
| Purity: | >98% |
| Molecular Weight: | 560.67 |
| Molecular Formula: | C29H32N6O4S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | AC-220, Quizartinib |
| Chemical Name: | N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Quizartinib (AC220) is an orally available small molecule with potential antineoplastic activity. Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis. Mutations in FLT3, resulting in constitutive activation, are the most frequent genetic alterations in acute myeloid leukemia (AML) and occur in approximately one-third of AML cases.For the detailed information of Quizartinib (AC220), the solubility of Quizartinib (AC220) in water, the solubility of Quizartinib (AC220) in DMSO, the solubility of Quizartinib (AC220) in PBS buffer, the animal experiment (test) of Quizartinib (AC220), the cell expriment (test) of Quizartinib (AC220), the in vivo, in vitro and clinical trial test of Quizartinib (AC220), the EC50, IC50,and Affinity of Quizartinib (AC220), Please contact DC Chemicals.
