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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 928037-13-2 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | N-[2-氟-4-[[2-[[[4-(4-甲基哌嗪-1-基)*-1-基]羰基]氨基]吡啶-4-基]氧基]苯基]-N'-(4-氟苯基)环丙烷-1,1-二甲酰胺 | 英文名 | Golvatinib |
|---|---|---|---|
| CAS号 | 928037-13-2 | 分子量 | 633.688 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 867.5±65.0 °C at 760 mmHg |
| 分子式 | C33H37F2N7O4 | 熔点 | N/A |
| MSDS | N/A | 闪点 | 478.5±34.3 °C |
E-7050是 c-Met 和 VEGFR2 的双重抑制剂，IC50值分别为14 和 16 nM。
Fields of Application :
E-7050 is hepatocyte growth factor receptors (HGFR).
| CAS Number: | 928037-13-2 |
| Purity: | >98% |
| Molecular Weight: | 633.69 |
| Molecular Formula: | C33H37F2N7O4 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | E-7060,E7050,E 7050 |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
golvatinib (also known as E7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. c-Met/VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c-Met and VEGFR-2, which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases. c-Met and VEGFR-2 are upregulated in a variety of various tumor cell types and play important roles in tumor cell growth, migration and angiogenesis.For the detailed information of Golvatinib (E7050), the solubility of Golvatinib (E7050) in water, the solubility of Golvatinib (E7050) in DMSO, the solubility of Golvatinib (E7050) in PBS buffer, the animal experiment (test) of Golvatinib (E7050), the cell expriment (test) of Golvatinib (E7050), the in vivo, in vitro and clinical trial test of Golvatinib (E7050), the EC50, IC50,and Affinity of Golvatinib (E7050), Please contact DC Chemicals.
