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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 870281-82-6 |
| 是否进口 | 否 |
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Fields of Application :
CAL-101 is a selective p110δ inhibitor with IC50 of 2.5 nM; shown to have 40- to 300-fold greater selectivity for p110δ thanp110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
| CAS Number: | 870281-82-6 |
| Purity: | >99.5%,ee purity>99% |
| Molecular Weight: | 415.423 |
| Molecular Formula: | C22H18FN7O |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | Idelalisib; CAL-101, GS-1101; GS 1101; GS1101,CAL101 |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Idelalisib, also known as CAL-101, is a PI3K-delta inhibitor with potential immunomodulating and antineoplastic activities. CAL-101 inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and thus inhibiting tumor cell proliferation, motility, and survival. Unlike other iso Forms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. CAL-101 has [EC(50)] = 8nM.For the detailed information of Idelalisib (CAL-101,GS-1101), the solubility of Idelalisib (CAL-101,GS-1101) in water, the solubility of Idelalisib (CAL-101,GS-1101) in DMSO, the solubility of Idelalisib (CAL-101,GS-1101) in PBS buffer, the animal experiment (test) of Idelalisib (CAL-101,GS-1101), the cell expriment (test) of Idelalisib (CAL-101,GS-1101), the in vivo, in vitro and clinical trial test of Idelalisib (CAL-101,GS-1101), the EC50, IC50,and Affinity of Idelalisib (CAL-101,GS-1101).
References:
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