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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1213269-23-8 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | N-[3-[[5-氯-2-[[2-甲氧基-4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氧基]苯基]-2-丙烯酰胺 | 英文名 | WZ4002 |
|---|---|---|---|
| CAS号 | 1213269-23-8 | 分子量 | 494.973 |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | N/A |
| 分子式 | C25H27ClN6O3 | 熔点 | N/A |
| MSDS | 中文版 美版 | 闪点 | N/A |
WZ4002是突变选择性的 EGFR 抑制剂；对EGFRL858R，EGFRL858R/T790M，EGFRE746_A750，EGFRE746_A750/T790M 的 IC50 值分别为2，8，3，2 nM。
Fields of Application :
WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM; does not inhibit ERBB2 phosphorylation (T798I).
| CAS Number: | 1213269-23-8 |
| Purity: | >99% |
| Molecular Weight: | 494.97 |
| Molecular Formula: | C25H27ClN6O3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | WZ4002,WZ 4002,WZ-4002 |
| Chemical Name: | N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
WZ4002 is EGFR inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib. WZ4002 has a basic chemical framework (covalent pyrimidine) which is different from that of other EGFR inhibitors. This agent is 30- to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against wildtype EGFR, than quinazoline-based EGFR inhibitors (HKI-272 and CL-387,785) in vitro.For the detailed information of WZ4002, the solubility of WZ4002 in water, the solubility of WZ4002 in DMSO, the solubility of WZ4002 in PBS buffer, the animal experiment (test) of WZ4002, the cell expriment (test) of WZ4002, the in vivo, in vitro and clinical trial test of WZ4002, the EC50, IC50,and Affinity of WZ4002, Please contact DC Chemicals.
