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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1227633-49-9 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | StemRegenin 1 | 英文名 | StemRegenin 1 |
|---|---|---|---|
| CAS号 | 1227633-49-9 | 分子量 | 429.537 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 622.9±65.0 °C at 760 mmHg |
| 分子式 | C24H23N5OS | 熔点 | N/A |
| MSDS | N/A | 闪点 | 330.5±34.3 °C |
StemRegenin 1 是一种有效的芳香烃受体 (AhR) 拮抗剂，IC50 为 127 nM。
Fields of Application :
StemRegenin 1 antagonizes hematopoietic stem cell differentiation.
| CAS Number: | 1227633-49-9 |
| Purity: | >98% |
| Molecular Weight: | 429.5 |
| Molecular Formula: | C24H23N5OS |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | SR 1,SR-1,SR1 |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Extending the pluripotency of hematopoietic stem cells (HSC) is of key importance to the application of stem cell therapies in a variety of diseases. Loss of the expression of the cell surface proteins CD34 and CD133 is one marker of HSC differentiation and thus often monitored in assays to test potential compounds that promote HSC expansion. StemRegenin 1 (SR1) is a purine derivative that antagonizes aryl hydrocarbon receptor signaling with an IC50 value of 127 nM in CD34+ cells, which results in sustained expression of CD34.1 Human embryonic stem cells cultured with SR1 show a 50-fold increase in cells expressing CD34 (EC50 = 120 nM) and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice.1 This effect is quickly reversed with removal of SR1, which leads to rapid cell differentiation.For the detailed information of StemRegenin 1, the solubility of StemRegenin 1 in water, the solubility of StemRegenin 1 in DMSO, the solubility of StemRegenin 1 in PBS buffer, the animal experiment (test) of StemRegenin 1, the cell expriment (test) of StemRegenin 1, the in vivo, in vitro and clinical trial test of StemRegenin 1, the EC50, IC50,and Affinity of StemRegenin 1, Please contact DC Chemicals.
