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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1195765-45-7 |
| 是否进口 | 否 |
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| 常用名 | 达拉菲尼 | 英文名 | Dabrafenib |
|---|---|---|---|
| CAS号 | 1195765-45-7 | 分子量 | 519.562 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 653.7±65.0 °C at 760 mmHg |
| 分子式 | C23H20F3N5O2S2 | 熔点 | N/A |
| MSDS | N/A | 闪点 | 349.2±34.3 °C |
Dabrafenib是ATP竞争型的 Raf 抑制剂，抑制 C-Raf 和 B-RafV600E 的 IC50 分别为 5 nM 和 0.6 nM。
Fields of Application :
Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively. Phase 3.
| CAS Number: | 1195765-45-7 |
| Purity: | >98% |
| Molecular Weight: | 519.56 |
| Molecular Formula: | C23H20F3N5O2S2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Dabrafenib is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.For the detailed information of Dabrafenib (GSK2118436), the solubility of Dabrafenib (GSK2118436) in water, the solubility of Dabrafenib (GSK2118436) in DMSO, the solubility of Dabrafenib (GSK2118436) in PBS buffer, the animal experiment (test) of Dabrafenib (GSK2118436), the cell expriment (test) of Dabrafenib (GSK2118436), the in vivo, in vitro and clinical trial test of Dabrafenib (GSK2118436), the EC50, IC50,and Affinity of Dabrafenib (GSK2118436), Please contact DC Chemicals.
