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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 912445-05-7 |
| 是否进口 | 否 |
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| 常用名 | 维利帕尼* | 英文名 | ABT-888 |
|---|---|---|---|
| CAS号 | 912445-05-7 | 分子量 | 317.214 |
| 密度 | N/A | 沸点 | N/A |
| 分子式 | C13H18Cl2N4O | 熔点 | N/A |
| MSDS | N/A | 闪点 | N/A |
Veliparib dihydrochloride 是一种有效的 PARP1 和 PARP2 抑制剂，在无细胞实验中，Ki 值分别为 5.2 nM 和 2.9 nM。
Fields of Application :
Veliparib is a potent inhibitor of both PARP-1 and PARP-2 by [3H]NAD+ with Kis of 5.2 and 2.9 nmol/L, respectively.
| CAS Number: | 912445-05-7 |
| Purity: | >98% |
| Molecular Weight: | 317.21 |
| Molecular Formula: | C13H18Cl2N4O |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | ABT 888,ABT888 |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Veliparib (ABT-888) is a poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities. With no antiproliferative effects as a single agent at therapeutic concentrations, ABT-888 inhibits PARPs, thereby inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents. PARP nuclear enzymes are activated by DNA single or double strand breaks, resulting in the poly(ADP-ribosyl)ation of other nuclear DNA binding proteins involved in DNA repair; poly(ADP-ribosyl)ation contributes to efficient DNA repair and to survival of proliferating cells exposed to mild genotoxic stresses as induced by as oxidants, alkylating agents or ionizing radiation.For the detailed information of Veliparib (ABT-888), the solubility of Veliparib (ABT-888) in water, the solubility of Veliparib (ABT-888) in DMSO, the solubility of Veliparib (ABT-888) in PBS buffer, the animal experiment (test) of Veliparib (ABT-888), the cell expriment (test) of Veliparib (ABT-888), the in vivo, in vitro and clinical trial test of Veliparib (ABT-888), the EC50, IC50,and Affinity of Veliparib (ABT-888), Please contact DC Chemicals.
