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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | T2398 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 99.75%% |
| CAS编号 | 540737-29-9 |
| 是否进口 | 否 |
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CAS 540737-29-9 分子式 C22H28N6O8 分子量 504.49
靶点： JAK1; JAK2; JAK3; Lck; ROCK2;
Tofacitinib citrate is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).
| 常用名 | 枸橼酸托法替尼 | 英文名 | Tofacitinib Citrate |
|---|---|---|---|
| CAS号 | 540737-29-9 | 分子量 | 504.493 |
| 密度 | N/A | 沸点 | N/A |
| 分子式 | C22H28N6O8 | 熔点 | N/A |
| MSDS | 中文版 美版 | 闪点 | N/A |
Tofacitinib citrate是 JAK1/2/3 抑制剂，IC50 分别为1，20 和 112 nM。
Fields of Application :
Tofacitinib is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent versus JAK2 and JAK1. Phase 3.
| CAS Number: | 540737-29-9 |
| Purity: | >98% |
| Molecular Weight: | 504.49 |
| Molecular Formula: | C22H28N6O8 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | CP-690550; Tofacitinib; tasocitinib |
| Chemical Name: | 3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Tofacitinib (trade name Xeljanz, Formerly tasocitinib, CP-690550) is a drug discovered and developed by Pfizer. It is currently approved For the treatment of rheumatoid arthritis (RA) in the United States and is being studied For treatment of psoriasis, inflammatory bowel disease, and other immunological diseases, as well as For the prevention of organ transplant rejection.For the detailed information of Tofacitinib (CP-690550) Citrate, the solubility of Tofacitinib (CP-690550) Citrate in water, the solubility of Tofacitinib (CP-690550) Citrate in DMSO, the solubility of Tofacitinib (CP-690550) Citrate in PBS buffer, the animal experiment (test) of Tofacitinib (CP-690550) Citrate, the cell expriment (test) of Tofacitinib (CP-690550) Citrate, the in vivo, in vitro and clinical trial test of Tofacitinib (CP-690550) Citrate, the EC50, IC50,and Affinity of Tofacitinib (CP-690550) Citrate, Please contact DC Chemicals.
