|
| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1032900-25-6 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | 色瑞替尼 | 英文名 | Ceritinib |
|---|---|---|---|
| CAS号 | 1032900-25-6 | 分子量 | 558.135 |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 720.7±70.0 °C at 760 mmHg |
| 分子式 | C28H36ClN5O3S | 熔点 | N/A |
| MSDS | N/A | 闪点 | 389.6±35.7 °C |
Ceritinib (LDK378) 是有效且特异性的 ALK 抑制剂，IC50 为 0.2 nM。
Fields of Application :
LDK378 is a highly selective ALK inhibitor with IC50 of 2 nM
| CAS Number: | 1032900-25-6 |
| Purity: | >99% |
| Molecular Weight: | 558.14 |
| Molecular Formula: | C28H36ClN5O3S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | LDK-378; LDK378,Ceritinib |
| Chemical Name: | 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
LDK378 is a selective inhibitor of ALK1, a target found in metastatic non-small cell lung cancer (NSCLC). In Phase I trials, LDK378 showed a marked clinical response in 78 patients with anaplastic lymphoma kinase positive (ALK+) metastatic non-small cell lung cancer (NSCLC) who had progressed during or after crizotinib therapy or had not been previously treated with crizotinib.For the detailed information of LDK378 (ALK1 inhibitor), the solubility of LDK378 (ALK1 inhibitor) in water, the solubility of LDK378 (ALK1 inhibitor) in DMSO, the solubility of LDK378 (ALK1 inhibitor) in PBS buffer, the animal experiment (test) of LDK378 (ALK1 inhibitor), the cell expriment (test) of LDK378 (ALK1 inhibitor), the in vivo, in vitro and clinical trial test of LDK378 (ALK1 inhibitor), the EC50, IC50,and Affinity of LDK378 (ALK1 inhibitor), Please contact DC Chemicals.
