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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1349796-36-6 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | PI3K-IN-1 | 英文名 | XL765 |
|---|---|---|---|
| CAS号 | 1349796-36-6 | 分子量 | 599.657 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | N/A |
| 分子式 | C31H29N5O6S | 熔点 | N/A |
| MSDS | N/A | 闪点 | N/A |
PI3K-IN-1是PI3K抑制剂，在WO2012103524 A2和WO2013147649 A2两个专利中被报道。
Fields of Application :
Voxtalisib (SAR245409, XL765) Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR.
| CAS Number: | 1349796-36-6 |
| Purity: | >98% |
| Molecular Weight: | 599.66 |
| Molecular Formula: | C31H29N5O6S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | SAR245409; XL-765;SAR 245409;SAR- 245409 |
| Chemical Name: | N-(4-(N-(3-((3,5-dimethoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-3-methoxy-4-methylbenzamide. |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
XL-765, also known as SAR245409, is a PI3K/mTOR dual kinase inhibitor XL765 is an orally bioavailable small molecule targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinases in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR dual kinase inhibitor XL765 inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in susceptible tumor cell populations. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent fashion in response to nutrient and energy deprivation. Accordingly, this agent maybe more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.For the detailed information of XL765 (SAR245409), the solubility of XL765 (SAR245409) in water, the solubility of XL765 (SAR245409) in DMSO, the solubility of XL765 (SAR245409) in PBS buffer, the animal experiment (test) of XL765 (SAR245409), the cell expriment (test) of XL765 (SAR245409), the in vivo, in vitro and clinical trial test of XL765 (SAR245409), the EC50, IC50,and Affinity of XL765 (SAR245409), Please contact DC Chemicals.
