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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 891494-63-6 |
| 是否进口 | 否 |
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| 常用名 | 6-溴-3-(1-甲基-1H-吡唑-4-基)-5-(3R)-3-*基吡唑并[1,5-A]嘧啶-7-胺 | 英文名 | SCH 900776 |
|---|---|---|---|
| CAS号 | 891494-63-6 | 分子量 | 376.254 |
| 密度 | 1.8±0.1 g/cm3 | 沸点 | N/A |
| 分子式 | C15H18BrN7 | 熔点 | N/A |
| MSDS | N/A | 闪点 | N/A |
SCH900776 是一种有效的，选择性的，可口服的 Chk1 抑制剂，IC50 值为 3 nM；对 CDK2 和 Chk2 的抑制作用稍弱，IC50值分别为 160 nM 和 1500 nM。
Fields of Application :
SCH 900776 is a selective Chk1 inhibitor with IC50 of 3 nM. It shows 50-fold selectivity against Chk2. Phase 2.
| CAS Number: | 891494-63-6 |
| Purity: | >98% |
| Molecular Weight: | 376.25 |
| Molecular Formula: | C15H18BrN7 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | SCH-900776; SCH 900776, MK-8776. |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
SCH900776, also known as MK-8776. is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor SCH 900776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents. Chk1 is an ATP-dependent serine-threonine kinase that in response to DNA damage phosphorylates cdc25 phosphatases, resulting in inhibitory tyrosine phosphorylation of CDK-cyclin complexes and cell cycle arrest.For the detailed information of MK-8776 (SCH 900776), the solubility of MK-8776 (SCH 900776) in water, the solubility of MK-8776 (SCH 900776) in DMSO, the solubility of MK-8776 (SCH 900776) in PBS buffer, the animal experiment (test) of MK-8776 (SCH 900776), the cell expriment (test) of MK-8776 (SCH 900776), the in vivo, in vitro and clinical trial test of MK-8776 (SCH 900776), the EC50, IC50,and Affinity of MK-8776 (SCH 900776), Please contact DC Chemicals.
