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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1268524-70-4 |
| 是否进口 | 否 |
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| 常用名 | (+)-JQ-1 | 英文名 | (+)-JQ-1 |
|---|---|---|---|
| CAS号 | 1268524-70-4 | 分子量 | 456.988 |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 610.4±65.0 °C at 760 mmHg |
| 分子式 | C23H25ClN4O2S | 熔点 | N/A |
| MSDS | 美版 | 闪点 | 322.9±34.3 °C |
(+)-JQ-1 是一种 BET bromodomain 抑制剂，抑制 BRD4(1/2) 的 IC50 分别为 77 nM 和 33 nM。
Fields of Application :
(+)-JQ1 is a BET bromodomain inhibitor, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family.
| CAS Number: | 1268524-70-4 |
| Purity: | HPLC Purity>99%,ee purity>99% |
| Molecular Weight: | 456.99 |
| Molecular Formula: | C23H25ClN4O2S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | JQ-1，JQ 1，JQ1，+JQ 1，+JQ-1，+JQ1 |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
(+)-JQ-1 is a potent, high Affinity selective BET bromodomain inhibitor (IC50 values are 17.7, 32.6, 76.9 and 12942 nM respectively For BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively; Kd values are 49, 59.5, 82, 90.1, 128 and 190 nM For BRD4 (N), BRD3 (N), BRD3 (C), BRD4 (C), BRD2 (N) and BRDT (N) respectively). Induces squamous differentiation in NUT midline carcinoma (NMC) cell lines; inhibits tumor growth in NMC xenograft models in vivo. Exhibits reversible contraceptive effects in germ cells from male mice.For the detailed information of (+)-JQ1, the solubility of (+)-JQ1 in water, the solubility of (+)-JQ1 in DMSO, the solubility of (+)-JQ1 in PBS buffer, the animal experiment (test) of (+)-JQ1, the cell expriment (test) of (+)-JQ1, the in vivo, in vitro and clinical trial test of (+)-JQ1, the EC50, IC50,and Affinity of (+)-JQ1, Please contact DC Chemicals.
