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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1372540-25-4 |
| 是否进口 | 否 |
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| 常用名 | 2-甲基-1-[[2-甲基-3-(三氟甲基)苯基]甲基]-6-(4-吗啉基)-1H-苯并咪唑-4-羧酸 | 英文名 | GSK-2636771 |
|---|---|---|---|
| CAS号 | 1372540-25-4 | 分子量 | 433.424 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 641.3±55.0 °C at 760 mmHg |
| 分子式 | C22H22F3N3O3 | 熔点 | N/A |
| MSDS | N/A | 闪点 | 341.7±31.5 °C |
GSK2636771是有效，选择性和可口服的 PI3Kβ 抑制剂，Ki和IC50分别为0.89，5.2 nM，比p110α和p110γ的选择性高900倍，比p110δ同种型的选择性高10倍。
Fields of Application :
GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor, sensitive to PTEN null cell lines. Phase 1/2a.
| CAS Number: | 1372540-25-4 |
| Purity: | 99% |
| Molecular Weight: | 433.42 |
| Molecular Formula: | C22H22F3N3O3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | |
| Chemical Name: | 1H-Benzimidazole-4-carboxylic acid, 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl) |
| Storage: | 2 years -20°C powder,2 weeks 4°C in DMSO,6 months -80°C in DMSO |
Note: Products for research use only, not for human use
Description:
GSK-2636771 shows selectively inhibitory activity in PTEN null cell lines (human prostate adenocarcinoma PC-3 and breast cancer HCC70) with EC50 of 36 nM and 72 nM, respectively. GSK-2636771 decreases phosphorylated protein kinase Akt (Ser473) levels in these xenograft models. GSK-2636771 (100 mg/kg) do not increase glucose/insulin levels in mice.For the detailed information of GSK2636771, the solubility of GSK2636771 in water, the solubility of GSK2636771 in DMSO, the solubility of GSK2636771 in PBS buffer, the animal experiment (test) of GSK2636771, the cell expriment (test) of GSK2636771, the in vivo, in vitro and clinical trial test of GSK2636771, the EC50, IC50,and Affinity of GSK2636771, Please contact DC Chemicals.
