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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1338466-77-5 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | EPZ004777 | 英文名 | EPZ004777 |
|---|---|---|---|
| CAS号 | 1338466-77-5 | 分子量 | 539.670 |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 740.7±60.0 °C at 760 mmHg |
| 分子式 | C28H41N7O4 | 熔点 | N/A |
| MSDS | N/A | 闪点 | 401.7±32.9 °C |
EPZ004777 是一种有效的选择性 DOT1L 抑制剂，IC50 为 0.4 nM。
Fields of Application :
EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
| CAS Number: | 1338466-77-5 |
| Purity: | >98% |
| Molecular Weight: | 539.67 |
| Molecular Formula: | C28H41N7O4 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | EPZ004777; EPZ 004777; EPZ-004777,PEZ4777,EPZ 4777,EPZ-4777 |
| Chemical Name: | 1-(3-((((2R,3S,4R,5R)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
EPZ004777 is a potent, selective inhibitor of DOT1L. Treatment of mixed lineage leukemia (MLL) cells with EPZ004777 selectively inhibits H3K79 methylation and blocks expression of leukemogenic genes. Exposure of leukemic cells to EPZ004777 results in selective killing of those cells bearing the MLL gene translocation, with little effect on non-MLL-translocated cells. Finally, in vivo administration of EPZ004777 leads to extension of survival in a mouse MLL xenograft model. These results provide compelling support For DOT1L inhibition as a basis For targeted therapeutics against MLL.For the detailed information of EPZ004777, the solubility of EPZ004777 in water, the solubility of EPZ004777 in DMSO, the solubility of EPZ004777 in PBS buffer, the animal experiment (test) of EPZ004777, the cell expriment (test) of EPZ004777, the in vivo, in vitro and clinical trial test of EPZ004777, the EC50, IC50,and Affinity of EPZ004777, Please contact DC Chemicals.
