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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 301836-41-9 |
| 是否进口 | 否 |
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Fields of Application :
SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases.
| CAS Number: | 301836-41-9 |
| Purity: | >98% |
| Molecular Weight: | 384.39 |
| Molecular Formula: | C22H16N4O3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | SB431542, SB 431542 |
| Chemical Name: | 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
SB-431542 is a novel small molecule inhibitor of the type I TGF-beta receptor, on a panel of human malignant glioma cell lines. SB-431542 blocked the phosphorylation and nuclear translocation of the SMADs, intracellular mediators of TGF-beta signaling, with decreased TGF-beta-mediated transcription. Furthermore, SB-431542 inhibited the expression of two critical effectors of TGF-beta-vascular endothelial growth factor and plasminogen activator inhibitor-1. SB-431542 treatment of glioma cultures inhibited proliferation, TGF-beta-mediated morphologic changes, and cellular motility. Together, our results suggest that small molecule inhibitors of TGF-beta receptors may offer a novel therapy For malignant gliomas by reducing cell proliferation, angiogenesis, and motility.For the detailed information of SB-431542, the solubility of SB-431542 in water, the solubility of SB-431542 in DMSO, the solubility of SB-431542 in PBS buffer, the animal experiment (test) of SB-431542, the cell expriment (test) of SB-431542, the in vivo, in vitro and clinical trial test of SB-431542, the EC50, IC50,and Affinity of SB-431542.
References:
C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
