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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 808118-40-3 |
| 是否进口 | 否 |
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| 常用名 | N-[(4-羟基-1-甲基-7-苯氧基-3-异喹啉)羰基]甘氨酸 | 英文名 | FG-4592 |
|---|---|---|---|
| CAS号 | 808118-40-3 | 分子量 | 352.341 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 684.3±55.0 °C at 760 mmHg |
| 分子式 | C19H16N2O5 | 熔点 | N/A |
| MSDS | N/A | 闪点 | 367.6±31.5 °C |
FG-4592 是一种口服的 HIF 脯氨酰羟化酶抑制剂，目前用于治疗贫血症。
Fields of Application :
FG-4592 is an HIF αprolyl hydroxylase inhibitor, stabilizes HIF-2 and induces EPO production.
| CAS Number: | 808118-40-3 |
| Purity: | >98% |
| Molecular Weight: | 352.34 |
| Molecular Formula: | C19H16N2O5 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | Roxadustat,ASP1517,ASP-1517,FG 4592，FG4592 |
| Chemical Name: | 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetic acid |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
FG-4592 is an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase currently in clinical development For the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism. A phase II clinical trial of FG-4592 has been competed in the treatment of chronic kidney disease.For the detailed information of FG-4592 (ASP1517), the solubility of FG-4592 (ASP1517) in water, the solubility of FG-4592 (ASP1517) in DMSO, the solubility of FG-4592 (ASP1517) in PBS buffer, the animal experiment (test) of FG-4592 (ASP1517), the cell expriment (test) of FG-4592 (ASP1517), the in vivo, in vitro and clinical trial test of FG-4592 (ASP1517), the EC50, IC50,and Affinity of FG-4592 (ASP1517), Please contact DC Chemicals.
