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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 459868-92-9 |
| 是否进口 | 否 |
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| 常用名 | 瑞卡帕布 | 英文名 | Rucaparib |
|---|---|---|---|
| CAS号 | 459868-92-9 | 分子量 | 421.359 |
| 密度 | N/A | 沸点 | 625.2oC at 760 mmHg |
| 分子式 | C19H21FN3O5P | 熔点 | N/A |
| MSDS | N/A | 闪点 | 331.9oC |
Rucaparib phosphate 是 PARP 抑制剂，能够抑制 PARP1，Ki 值为 1.4 nM。
Fields of Application :
Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM with binding affinity to nine PARP domains. Phase 1/2.
| CAS Number: | 459868-92-9 |
| Purity: | >98% |
| Molecular Weight: | 421.36 |
| Molecular Formula: | C19H18FN3O.H3PO4 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | AG-14699 (as phosphate salt), AG-014447 (as free base); Rucaparib; PF-01367338; AG014699; |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Rucaparib (AG-14699 or PF-01367338) is a tricyclic indole poly(ADP-Ribose) polymerase (PARP1) inhibitor with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Rucaparib selectively binds to PARP1 and inhibits PARP1-mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. This may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARP1 catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks.For the detailed information of Rucaparib (AG-14699, PF-01367338), the solubility of Rucaparib (AG-14699, PF-01367338) in water, the solubility of Rucaparib (AG-14699, PF-01367338) in DMSO, the solubility of Rucaparib (AG-14699, PF-01367338) in PBS buffer, the animal experiment (test) of Rucaparib (AG-14699, PF-01367338), the cell expriment (test) of Rucaparib (AG-14699, PF-01367338), the in vivo, in vitro and clinical trial test of Rucaparib (AG-14699, PF-01367338), the EC50, IC50,and Affinity of Rucaparib (AG-14699, PF-01367338), Please contact DC Chemicals.
