|
| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 944396-07-0 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | 5-[2,6-二(4-吗啉基)-4-嘧啶基]-4-(三氟甲基)-2-吡啶胺 | 英文名 | NVP-BKM120 |
|---|---|---|---|
| CAS号 | 944396-07-0 | 分子量 | 410.393 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 645.7±65.0 °C at 760 mmHg |
| 分子式 | C18H21F3N6O2 | 熔点 | N/A |
| MSDS | N/A | 闪点 | 344.3±34.3 °C |
NVP-BKM120 是一种 pan-class I PI3K 抑制剂，作用于 p110α/p110β/p110δ/p110γ，IC50 分别为 52 nM/166 nM/116 nM/262 nM。
Fields of Application :
BKM120 is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ.
| CAS Number: | 944396-07-0 |
| Purity: | >98% |
| Molecular Weight: | 410.39 |
| Molecular Formula: | C18H21F3N6O2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | NVP-BKM-120, BKM-120; Buparlisib |
| Chemical Name: | 5-(2,6-dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Buparlisib, also known as BKM120, is an orally bioavailable specific oral inhibitor of the pan-class I phosphatidylinositol 3-kinase (PI3K) family of lipid kinases with potential antineoplastic activity. PI3K inhibitor BKM120 specifically inhibits class I PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway in an ATP-competitive manner, thereby inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate and activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.For the detailed information of BKM120 (NVP-BKM120, Buparlisib), the solubility of BKM120 (NVP-BKM120, Buparlisib) in water, the solubility of BKM120 (NVP-BKM120, Buparlisib) in DMSO, the solubility of BKM120 (NVP-BKM120, Buparlisib) in PBS buffer, the animal experiment (test) of BKM120 (NVP-BKM120, Buparlisib), the cell expriment (test) of BKM120 (NVP-BKM120, Buparlisib), the in vivo, in vitro and clinical trial test of BKM120 (NVP-BKM120, Buparlisib), the EC50, IC50,and Affinity of BKM120 (NVP-BKM120, Buparlisib), Please contact DC Chemicals.
