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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1197958-12-5 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | 布格替尼 | 英文名 | ALK-IN-1 |
|---|---|---|---|
| CAS号 | 1197958-12-5 | 分子量 | 529.014 |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 737.6±70.0 °C at 760 mmHg |
| 分子式 | C26H34ClN6O2P | 熔点 | N/A |
| MSDS | N/A | 闪点 | 399.9±35.7 °C |
ALK-IN-1是ALK激酶高效选择性抑制剂，出自专利US20140066406 A1。
Fields of Application :
AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 1/2.
| CAS Number: | 1197958-12-5 |
| Purity: | >98% |
| Molecular Weight: | 529.01 |
| Molecular Formula: | C26H34ClN6O2P |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | AP-26113; AP26113; AP 26113,Brigatinib |
| Chemical Name: | (2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
AP26113 is an orally available inhibitor of receptor tyrosine kinases anaplastic lymphoma kinase (ALK) and the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Dual ALK/EGFR inhibitor AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant Forms. This leads to the inhibition of ALK kinase and EGFR kinase, disrupts their signaling pathways and eventually inhibits tumor cell growth in susceptible tumor cells. In addition, AP26113 appears to overcome mutation-based resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; ALK dysregulation and gene rearrangements are associated with a series of tumors. EGFR is overexpressed in a variety of cancer cell types.For the detailed information of AP26113, the solubility of AP26113 in water, the solubility of AP26113 in DMSO, the solubility of AP26113 in PBS buffer, the animal experiment (test) of AP26113, the cell expriment (test) of AP26113, the in vivo, in vitro and clinical trial test of AP26113, the EC50, IC50,and Affinity of AP26113, Please contact DC Chemicals.
