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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1269440-17-6 |
| 是否进口 | 否 |
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| 常用名 | Encorafenib | 英文名 | LGX818 |
|---|---|---|---|
| CAS号 | 1269440-17-6 | 分子量 | 540.011 |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | N/A |
| 分子式 | C22H27ClFN7O4S | 熔点 | N/A |
| MSDS | N/A | 闪点 | N/A |
Encorafenib (LGX818) 是一种高效的 RAF 抑制剂，对BRAFV600E 细胞有选择性抗增殖和促凋亡活性，EC50 值为4 nM。
Fields of Application :
LGX818 is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.
| CAS Number: | 1269440-17-6 |
| Purity: | >98% |
| Molecular Weight: | 540.01 |
| Molecular Formula: | C22H27ClFN7O4S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | LGX 818; LGX-818，LGX818 |
| Chemical Name: | methylN-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
LGX818 is a drug candidate for the treatment of melanoma with the V600E mutation in the B-RAF kinase. The substance is being developed by Novartis, is in phase III clinical trials, and was disclosed at the spring 2013 American Chemical Society meeting in New Orleans. For the detailed information of LGX-818, the solubility of LGX-818 in water, the solubility of LGX-818 in DMSO, the solubility of LGX-818 in PBS buffer, the animal experiment (test) of LGX-818, the cell expriment (test) of LGX-818, the in vivo, in vitro and clinical trial test of LGX-818, the EC50, IC50,and Affinity of LGX-818, Please contact DC Chemicals.
