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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 102121-60-8 |
| 是否进口 | 否 |
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Fields of Application :
A retinoic acid analog and selective RARα agonist
| CAS Number: | 102121-60-8 |
| Purity: | >98% |
| Molecular Weight: | 351.44 |
| Molecular Formula: | C22H25NO3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | AM-580,AM 580,CD336; NSC608001; Ro 40-6055 |
| Chemical Name: | 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]benzoicacid |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
AM 580 is a selective retinoic acid analog, which is useful in vitro as a RARα agonist. Studies indicate that RARα increases the signaling of the RARα receptor to prevent intracellular and extracellular Amyloid β accumulation. In addition, this receptor increases the expression of disintegrin and metalloprotease. Since Amyloid β accumulation is a major finding in Alzheimer's disease (AD), AM 580 can be used to study this disease in vitro. AM 580 also induces the functions of IL-4, IL-5 and IL-13 and suppresses the production of IL-12 and IFNγ. Alternate studies suggest that AM 580 inhibits tumor proliferation, via reducing the level of RARγ. AM 580 is an activator of RAR β and RAR γ.For the detailed information of AM580, the solubility of AM580 in water, the solubility of AM580 in DMSO, the solubility of AM580 in PBS buffer, the animal experiment (test) of AM580, the cell expriment (test) of AM580, the in vivo, in vitro and clinical trial test of AM580, the EC50, IC50,and Affinity of AM580.
References:
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