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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 202590-98-5 |
| 是否进口 | 否 |
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Fields of Application :
OTX-015 is a new potent BRD2/3/4 inhibitor with evident anti-proliferative activity in several cell lines representative of mature B-cell tumors.
| CAS Number: | 202590-98-5 |
| Purity: | HPLC Purity>99%,ee purity>99% |
| Molecular Weight: | 491.99 |
| Molecular Formula: | C25H22ClN5O2S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | OTX 015; OTX015,MK-8628; MK 8628; MK8628,OTX-015 |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
OTX-015 is a new potent BRD-inhibitor with evident anti-proliferative activity in several cell lines representative of mature B-cell tumors. in vitro: OTX-015 demonstrated anti-proliferative activity in DLBCL cell lines (median IC50 0.192 uM). Similar results were obtained on SMZL (median IC50 0.165 uM), and on MM cell lines (median IC50 0.449 uM). MCL cell lines appeared less sensitive to OTX-015 (median IC50 2.01 uM). Among DLBCL cell lines, there was no difference based upon the cell of origin of the cell lines. OTX-105 caused a cell cycle arrest in G1 in a dose-dependent manner in 5/5 DLBCL and 3/3 MM cell lines, without an increase in cell death. Clinical trial: A Phase I, Dose-finding Study of the Bromodomain (Brd) Inhibitor OTX-015 in Hematological Malignancies. Phase 1. For the detailed information of OTX-015, the solubility of OTX-015 in water, the solubility of OTX-015 in DMSO, the solubility of OTX-015 in PBS buffer, the animal experiment (test) of OTX-015, the cell expriment (test) of OTX-015, the in vivo, in vitro and clinical trial test of OTX-015, the EC50, IC50,and Affinity of OTX-015.
References:
CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)NC4=CC=C(C=C4)O)C5=CC=C(C=C5)Cl)C
