|
| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 423735-93-7 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
Fields of Application :
Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.
| CAS Number: | 423735-93-7 |
| Purity: | >98% |
| Molecular Weight: | 361.23 |
| Molecular Formula: | C17H17BrN2O2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | ML161,ML-161 |
| Chemical Name: | Benzamide,2-bromo-N-[3-[(1-oxobutyl)amino]phenyl]- |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
ML-161 is an allosteric inhibitor of PAR1. ML-161 displays dose-dependent inhibition of thrombin-induced platelet activation, as measured by P-selectin expression. ML-161 displays selective inhibition of SFLLRN and thrombin-induced platelet aggregation, both of which operate via PAR1, and has no effect on AYPGKF, thromboxane, or ADP-induced platelet aggregation, which are all agonists at alternative platelet GPCRs. For the detailed information of ML 161, the solubility of ML 161 in water, the solubility of ML 161 in DMSO, the solubility of ML 161 in PBS buffer, the animal experiment (test) of ML 161, the cell expriment (test) of ML 161, the in vivo, in vitro and clinical trial test of ML 161, the EC50, IC50,and Affinity of ML 161.
References:
C(NC1=CC=CC(NC(=O)CCC)=C1)(=O)C1=CC=CC=C1Br
