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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 783348-36-7 |
| 是否进口 | 否 |
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Fields of Application :
MLN120B is a potent and effective IKKbeta inhibitor.
| CAS Number: | 783348-36-7 |
| Purity: | >98% |
| Molecular Weight: | 366.801 |
| Molecular Formula: | C19H15ClN4O2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | ML120B; MLN 120B; MLN-120B |
| Chemical Name: | N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylpyridine-3-carboxamide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
MLN120B inhibits both baseline and tumor necrosis factor-alpha-induced nuclear factor-kappaB activation, associated with down-regulation of IkappaBalpha and p65 nuclear factor-kappaB phosphorylation. MLN120B triggers 25% to 90% growth inhibition in a dose-dependent fashion in multiple myeloma cell lines and significantly augments tumor necrosis factor-alpha-induced cytotoxicity in MM.1S cells.For the detailed information of MLN-120B, the solubility of MLN-120B in water, the solubility of MLN-120B in DMSO, the solubility of MLN-120B in PBS buffer, the animal experiment (test) of MLN-120B, the cell expriment (test) of MLN-120B, the in vivo, in vitro and clinical trial test of MLN-120B, the EC50, IC50,and Affinity of MLN-120B.
References:
CC1=C(C=CC=N1)C(=O)NC2=C3C(=CC(=C2OC)Cl)C4=C(N3)C=NC=C4
