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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 7497-07-6 |
| 是否进口 | 否 |
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Fields of Application :
NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP.
| CAS Number: | 7497-07-6 |
| Purity: | >98% |
| Molecular Weight: | 260.16 |
| Molecular Formula: | C12H15Cl2NO |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | NSC405020,NSC-405020 |
| Chemical Name: | 3,4-Dichloro-N-(1-methylbutyl)benza-mide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP. NSC 405020 affects PEX homodimerization but not catalytic activity of MT1-MMP. NSC 405020 (100μM) inhibits migration of cells with high level of MT1-MMP, with a reduction of migration efficiency by about 75%. NSC 405020 does not inhibit migration of cells with low level of MT1-MMP and does not inhibit cell adhesion on collagen. NSC 405020 (0.5 mg/kg, intratumoral injection) significantly represses tumor growth. NSC 405020 causes a fibrotic, ΔPEX-like tumor phenotype and increases the level of COL-I. For the detailed information of NSC 405020, the solubility of NSC 405020 in water, the solubility of NSC 405020 in DMSO, the solubility of NSC 405020 in PBS buffer, the animal experiment (test) of NSC 405020, the cell expriment (test) of NSC 405020, the in vivo, in vitro and clinical trial test of NSC 405020, the EC50, IC50,and Affinity of NSC 405020.
References:
C(NC(C)CCC)(=O)C1=CC=C(Cl)C(Cl)=C1
