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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1061353-68-1 |
| 是否进口 | 否 |
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Fields of Application :
PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM.
| CAS Number: | 1061353-68-1 |
| Purity: | >98% |
| Molecular Weight: | 501.5 |
| Molecular Formula: | C25H26F3N5O3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | SR-2516; PND 1186; PND1186; SR 2516; SR2516 |
| Chemical Name: | 2-((2-((2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamidehydrochloride. |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
PND-1186, also known as SR-2156, is a potent FAK inhibitor with a 50% inhibitory concentration (IC50) of 1.5 nM in vitro. PND-1186 has an IC50 of ~100 nM in breast carcinoma cells. Notably, 1.0 μM PND-1186 (>5-fold above IC50) had limited effects on cell proliferation. However, under non-adherent conditions as spheroids and as colonies in soft agar, 0.1 μM PND-1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase-3 activation, and triggered cell apoptosis. PND-1186 inhibited 4T1 breast carcinoma subcutaneous tumor growth correlated with elevated tumor cell apoptosis and caspase 3 activation. Addition of PND-1186 to the drinking water of mice was well tolerated and inhibited ascites- and peritoneal membrane-associated ovarian carcinoma tumor growth associated with the inhibition of FAK Tyr-397 phosphorylation.For the detailed information of PND-1186, the solubility of PND-1186 in water, the solubility of PND-1186 in DMSO, the solubility of PND-1186 in PBS buffer, the animal experiment (test) of PND-1186, the cell expriment (test) of PND-1186, the in vivo, in vitro and clinical trial test of PND-1186, the EC50, IC50,and Affinity of PND-1186.
References:
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