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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1173097-76-1 |
| 是否进口 | 否 |
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Fields of Application :
U0126-EtOH(U-0126) is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD098059.
| CAS Number: | 1173097-76-1 |
| Purity: | >98% |
| Molecular Weight: | 426.56 |
| Molecular Formula: | C18H16N6S2.C2H6O |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | U0126-EtOH; U 0126; U-0126 |
| Chemical Name: | 1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Potent and selective non-competitive inhibitor of MAP kinase kinase. Inhibits MEK-1 and MEK-2 (IC50values of 0.07 and 0.06 μM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Centrally active following systemic administration in vivo. Also available as part of the MAPK Cascade Inhibitor Tocriset? and MAPK Inhibitor Tocriset?. Negative control U0124 (Cat. No. 1868) also available.For the detailed information of U0126, the solubility of U0126 in water, the solubility of U0126 in DMSO, the solubility of U0126 in PBS buffer, the animal experiment (test) of U0126, the cell expriment (test) of U0126, the in vivo, in vitro and clinical trial test of U0126, the EC50, IC50,and Affinity of U0126.
References:
CCO.C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N
