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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1144035-53-9 |
| 是否进口 | 否 |
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Fields of Application :
PF-8380 is a potent and specofic autotaxin inhibitor with an IC50 value of 2.8 nM.
| CAS Number: | 1144035-53-9 |
| Purity: | >98% |
| Molecular Weight: | 478.33 |
| Molecular Formula: | C22H21Cl2N3O5 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | PF 8380; PF8380 |
| Chemical Name: | 3,5-Dichlorobenzyl-[4-[3-oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]]piperazine-1-carboxylate |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Potent autotaxin inhibitor (IC50 = 2.8 nM in isolated enzyme assay; 101 nM in human whole blood). Modulates lysophosphatidic acid (LPA) levels in vivo and in vitro by directly inhibiting autotaxin; reduces LPA levels both in plasma and at site of inflammation. Orally available.For the detailed information of PF-8380, the solubility of PF-8380 in water, the solubility of PF-8380 in DMSO, the solubility of PF-8380 in PBS buffer, the animal experiment (test) of PF-8380, the cell expriment (test) of PF-8380, the in vivo, in vitro and clinical trial test of PF-8380, the EC50, IC50,and Affinity of PF-8380.
References:
C1CN(CCN1CCC(=O)C2=CC3=C(C=C2)NC(=O)O3)C(=O)OCC4=CC(=CC(=C4)Cl)Cl
