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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 483367-10-8 |
| 是否进口 | 否 |
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Fields of Application :
Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM.
| CAS Number: | 483367-10-8 |
| Purity: | >98% |
| Molecular Weight: | 520.62 |
| Molecular Formula: | C31H32N6O2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | |
| Chemical Name: | 9H-Purin-6-amine,9-cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)- |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Purmorphamine activates the Hedgehog pathway by directly binds and activates Smoothened with IC50 of ~ 1.5 μM in compete with cyclopamine, a Smo antagonist. Purmorphamine is a potent inducer of osteogenesis in multipotent C3H10T1/2 cells. The EC50 (based on ALP expression) For Purmorphamine is 1 μM in C3H10T1/2 cells. Purmorphamine (1 μM) and BMP-4 (100 ng/mL) together increase ALP activity more than 90-fold in 3T3-L1 cells. In contrast to BMP-4, Purmorphamine induces osteogenesis by activating Hedgehog signaling in multipotent mesenchymal progenitor cells. Purmorphamine up-regulates ALP expression in human mesenchymal stem cell-based constructs on rats. For the detailed information of Purmorphamine, the solubility of Purmorphamine in water, the solubility of Purmorphamine in DMSO, the solubility of Purmorphamine in PBS buffer, the animal experiment (test) of Purmorphamine, the cell expriment (test) of Purmorphamine, the in vivo, in vitro and clinical trial test of Purmorphamine, the EC50, IC50,and Affinity of Purmorphamine.
References:
C1CCC(CC1)N2C=NC3=C2N=C(N=C3NC4=CC=C(C=C4)N5CCOCC5)OC6=CC=CC7=CC=CC=C76
