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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 212844-54-7 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
Fields of Application :
Purvalanol B(NG-95) is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.
| CAS Number: | 212844-54-7 |
| Purity: | >98% |
| Molecular Weight: | 432.9 |
| Molecular Formula: | C20H25ClN6O3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | NG 95; NG95; NG-95 |
| Chemical Name: | 2-chloro-4-[[2-[[(2R)-1-hydroxy-3-methylbutan-2-yl]amino]-9-propan-2-ylpurin-6-yl]amino]benzoicacid |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Purvalanol B has been shown to be a cyclin-dependent kinase inhibitor. IC50 values are 6, 6, 9, > 10,000, and 6 nM For cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. This compound has also been shown to have antiproliferative properties, mediated by p42/p44 MAPK. IC50 Value: 6 nM (CDK1/cyclinB); 9 nM (cdk2/cyclin E); 6 nM (cdk5/p35 ) Target：CDKs in vitro: In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes is 6 nM (IC50) . In addition to CDK1, p42/p44 MAPK were found to be two major purvalanol-interacting proteins in five different mammalian cell lines (CCL39, PC12, HBL100, MCF-7 and Jurkat cells), suggesting the generality of the purvalanol/p42/p44 MAPK interaction. When cells were treated with purvalanol, p42/p44 MAPK and CDK1 activities were inhibited in a dose-dependent manner. Furthermore, purvalanol inhibited the nuclear accumulation of p42/p44 MAPK, an event dependent on the catalytic activity of these kinases .For the detailed information of Purvalanol B(NG-95), the solubility of Purvalanol B(NG-95) in water, the solubility of Purvalanol B(NG-95) in DMSO, the solubility of Purvalanol B(NG-95) in PBS buffer, the animal experiment (test) of Purvalanol B(NG-95), the cell expriment (test) of Purvalanol B(NG-95), the in vivo, in vitro and clinical trial test of Purvalanol B(NG-95), the EC50, IC50,and Affinity of Purvalanol B(NG-95).
References:
CC(C)[C@H](CO)NC1=NC2=C(C(=N1)NC3=CC(=C(C=C3)C(=O)O)Cl)N=CN2C(C)C
