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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 138489-18-6 |
| 是否进口 | 否 |
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Fields of Application :
Ro 31-8220 mesylate (Bisindolylmaleimide IX) is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively.
| CAS Number: | 138489-18-6 |
| Purity: | >98% |
| Molecular Weight: | 553.65 |
| Molecular Formula: | C25H23N5O2S.CH4O3S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | Ro 31-8220 methanesulfonate; Bisindolylmaleimide IX mesylate,Ro318220 |
| Chemical Name: | Carbamimidothioicacid,3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propylester,methanesulfonate(1:1) |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Ro 31-8220 inhibits rat brain PKC activity with IC50 of 23 nM, and does not show any high degree of selectivity between PKC-α, PKC-β, PKC-γ, and PKC-ε. Ro 31-8220 also inhibits MSK1, MAPKAPK1, RSK, GSK3β and S6K1 with a potency similar to that For PKC. In addition, Ro 31-8220 inhibits voltage-dependent Na+ channels. Ro 31-8220 alters cellular protein kinase C localization and potently inhibits growth of A549 and MCF-7 cells with IC50 of 0.78 μM and 0.897 μM, respectively. RO 31-8220 enhances epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation. Ro 31-8220 significantly decreases apoE secretion from primary human macrophages by inhibiting vesicular transport of apoE to the plasma membrane without significantly affecting apoE mRNA or apoE protein levels. [5]For the detailed information of Ro 31-8220 mesylate, the solubility of Ro 31-8220 mesylate in water, the solubility of Ro 31-8220 mesylate in DMSO, the solubility of Ro 31-8220 mesylate in PBS buffer, the animal experiment (test) of Ro 31-8220 mesylate, the cell expriment (test) of Ro 31-8220 mesylate, the in vivo, in vitro and clinical trial test of Ro 31-8220 mesylate, the EC50, IC50,and Affinity of Ro 31-8220 mesylate.
References:
CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O
