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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 587841-73-4 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | ZCL278 | 英文名 | ZCL 278 |
|---|---|---|---|
| CAS号 | 587841-73-4 | 分子量 | 584.894 |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | N/A |
| 分子式 | C21H19BrClN5O4S2 | 熔点 | N/A |
| MSDS | N/A | 闪点 | N/A |
ZCL278 是一种选择性的 Cdc42 调节剂，直接结合到 Cdc42，且抑制其功能，Kd 为 11.4 μM。
Fields of Application :
ZCL278 is a Cdc42 small molecule modulator that directly binds to Cdc42 (Kd=11.4 uM) and inhibits Cdc42-intersectin interaction.
| CAS Number: | 587841-73-4 |
| Purity: | >98% |
| Molecular Weight: | 584.89 |
| Molecular Formula: | C21H19BrClN5O4S2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | ZCL278; ZCL-278 |
| Chemical Name: | 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-?[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]pheny?l]amino]thioxomethyl]acetamide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
ZCL278 inhibits Cdc42 GTPase activity by the competition with GTP and inhibits Rac/Cdc42 phosphorylation in a time-dependent manner. ZCL278 (50 μM) inhibits Cdc42-mediated microspike Formation and disrupts GM130-docked Golgi structures in serum-starved Swiss 3T3 fibroblasts. In addition, ZCL278 also suppresses Cdc42-mediated neuronal branching and growth cone dynamics as well as actin-based motility and migration in a metastatic prostate cancer PC-3 cell line without cytotoxicity. For the detailed information of ZCL 278, the solubility of ZCL 278 in water, the solubility of ZCL 278 in DMSO, the solubility of ZCL 278 in PBS buffer, the animal experiment (test) of ZCL 278, the cell expriment (test) of ZCL 278, the in vivo, in vitro and clinical trial test of ZCL 278, the EC50, IC50,and Affinity of ZCL 278.
References:
CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)NC(=S)NC(=O)COC3=C(C=C(C=C3)Br)Cl)C
