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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 278779-30-9 |
| 是否进口 | 否 |
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| 常用名 | 3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑 | 英文名 | GW-4064 |
|---|---|---|---|
| CAS号 | 278779-30-9 | 分子量 | 542.838 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 702.1±60.0 °C at 760 mmHg |
| 分子式 | C28H22Cl3NO4 | 熔点 | N/A |
| MSDS | 中文版 美版 | 闪点 | 378.4±32.9 °C |
GW 4064 是一种有效的 FXR 激动剂，EC50 为 65 nM。
Fields of Application :
GW 4064 is a selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM).
| CAS Number: | 278779-30-9 |
| Purity: | >98% |
| Molecular Weight: | 542.84 |
| Molecular Formula: | C28H22Cl3NO4 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | GW4064,GW 4064 |
| Chemical Name: | Benzoic acid, 3-[2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]- |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
GW 4064 is a full agonist with EC50 values of 80 and 90 nM, respectively, in CV-1 cells transfected with mouse and human FXR expression vectors and an established reporter gene. There is no activity of GW 4064 on other nuclear receptors, including the retinoic acid receptor, at concentrations up to 1 μM. Thus, GW 4064 is a potent and selective nonsteroidal FXR agonist. Pharmacokinetic analysis in rats shows that GW 4064 possesses an oral bioavailability of 10% with a t1/2 = 3.5 h. Fisher rats are dosed with GW 4064 by oral gavage. After 7 days, a dose-dependent lowering of serum triglycerides is observed in the rats receiving GW 4064, with an ED50 = 20 mg/kg. For the detailed information of GW-4064, the solubility of GW-4064 in water, the solubility of GW-4064 in DMSO, the solubility of GW-4064 in PBS buffer, the animal experiment (test) of GW-4064, the cell expriment (test) of GW-4064, the in vivo, in vitro and clinical trial test of GW-4064, the EC50, IC50,and Affinity of GW-4064.
References:
CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC(=C(C=C3)/C=C/C4=CC(=CC=C4)C(=O)O)Cl
