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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1227163-84-9 |
| 是否进口 | 否 |
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| 常用名 | AZD3839自由基 | 英文名 | AZD 3839 |
|---|---|---|---|
| CAS号 | 1227163-84-9 | 分子量 | 431.413 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 596.3±60.0 °C at 760 mmHg |
| 分子式 | C24H16F3N5 | 熔点 | N/A |
| MSDS | N/A | 闪点 | 314.4±32.9 °C |
AZD3839 (free base)是一个强的和选择性的BACE1 inhibitor，IC50是23.6 uM, 也是β-secretase酶的抑制剂。
Fields of Application :
AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
| CAS Number: | 1227163-84-9 |
| Purity: | >98% |
| Molecular Weight: | 431.41 |
| Molecular Formula: | C24H16F3N5 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | AZD3839,AZD-3839,AZD 3839 |
| Chemical Name: | (S)-3-(2-(difluoromethyl)pyridin-4-yl)-7-fluoro-3-(3-(pyrimidin-5-yl)phenyl)-3H-isoindol-1-amine |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
In SH-SY5Y cells, AZD3839 efficiently decreases the Aβ40 levels with IC50 of 4.8 nM, and decreases the formation of sAPPβ with IC50 of 16.7 nM. AZD3839 also decreases the Aβ40 levels secreted from C57BL/6 mouse primary cortical neurons, N2A cells, and Dunkin-Hartley guinea pig primary cortical neurons with IC50 values of 50.9, 32.2, and 24.8 nM, respectively. AZD3839 causes in vitro BACE1 inhibition in the cell assay with IC50 value of 16.7 nM. In C57BL/6 mice, AZD3839 (69 mg/kg, p.o.) causes a dose- and time-dependent reduction of plasma and brain Aβ. In guinea pig and non-human primates, AZD3839 also inhibits Aβ generation. For the detailed information of AZD3839, the solubility of AZD3839 in water, the solubility of AZD3839 in DMSO, the solubility of AZD3839 in PBS buffer, the animal experiment (test) of AZD3839, the cell expriment (test) of AZD3839, the in vivo, in vitro and clinical trial test of AZD3839, the EC50, IC50,and affinity,of AZD3839, For the detailed information of AZD3839, the solubility of AZD3839 in water, the solubility of AZD3839 in DMSO, the solubility of AZD3839 in PBS buffer, the animal experiment (test) of AZD3839, the cell expriment (test) of AZD3839, the in vivo, in vitro and clinical trial test of AZD3839, the EC50, IC50,and affinity,of AZD3839.
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