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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1883429-21-7 |
| 是否进口 | 否 |
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Fields of Application :
BI-7273 is a potent, selective, and cell-permeable BRD9 BD Inhibitor.
| CAS Number: | 1883429-21-7 |
| Purity: | >98% |
| Molecular Weight: | 353.41 |
| Molecular Formula: | C20H23N3O3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | BI 7273,BI7273 |
| Chemical Name: | 4-(4-((dimethylamino)methyl)-2,6-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
BI-7273 is a potent, selective, and cell-permeable BRD9 BD Inhibitor with Kd (BRD9, ITC) = 15 nM and Kd (BRD9, DiscoveRx) = 0.75 nM. IC50 (BRD9 alpha assay ) = 19nm. BI-7273 proves to be invaluable as tools to further explore BRD9 biology. Components of the chromatin remodelling SWI/SNF complex are recurrently mutated in tumours, suggesting that altering the activity of the complex plays a role in oncogenesis. BRD9, a SWI/SNF subunit, play an important role in leukemia growth. The BRD9 bromodomain (BD) was shown to be required for the proliferation of acute myeloid leukemia (AML) cells.
References:
O=C1N(C)C=C(C2=C(OC)C=C(CN(C)C)C=C2OC)C3=CC=NC=C13
