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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1379545-95-5 |
| 是否进口 | 否 |
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| 常用名 | M2698 | 英文名 | M2698 |
|---|---|---|---|
| CAS号 | 1379545-95-5 | 分子量 | 449.863 |
| 密度 | N/A | 沸点 | N/A |
| 分子式 | C21H19ClF3N5O | 熔点 | N/A |
| MSDS | N/A | 闪点 | N/A |
Fields of Application :
M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier.
| CAS Number: | 1379545-95-5 |
| Purity: | >98% |
| Molecular Weight: | 449.12 |
| Molecular Formula: | C21H19ClF3N5O |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | M2698; M-2698; M 2698; MSC-2363318A; MSC 2363318A; MSC2363318A |
| Chemical Name: | (S)-4-((2-(azetidin-1-yl)-1-(4-chloro-3-(trifluoromethyl)phenyl)ethyl)amino)quinazoline-8-carboxamide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
M2698, also known as MSC-2363318A, is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. M2698 was highly potent in vitro (IC50 1 nM for p70S6K, Akt1 and Akt3 inhibition; IC50 17 nM for pGSK3β indirect inhibition) and in vivo (IC50 15 nM for pS6 indirect inhibition), and relatively selective (only 6/264 kinases had an IC50 within 10-fold of p70S6K).
References:
O=C(C1=CC=CC2=C(N[C@@H](C3=CC=C(Cl)C(C(F)(F)F)=C3)CN4CCC4)N=CN=C12)N
