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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | CS-B1167 |
| 用途 | 标准品 |
| 包装规格 | 50mg |
| 纯度 | 99.84%% |
| CAS编号 | 4360-12-7 |
| 是否进口 | 否 |
| Description | Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC50 of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia[1] [2] . |
|---|---|
| In Vitro | Electrophysiological experiments are performed with human embryonic kidney (HEK) cells (whole-cell patch clamp) and Xenopus oocytes (double-electrode voltage clamp) expressing wild-type and mutant HERG channels. Ajmaline blocks HERG currents with an IC50 of 1.0μM in HEK cells and 42.3μM in Xenopus oocytes[2] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Clinical Trial | NCT NumberSponsorConditionStart DatePhaseNCT02641431IRCCS Policlinico S. DonatoBrugada SyndromeNovember 16, 2015Not ApplicableNCT03491475Universitair Ziekenhuis BrusselBrugada SyndromeMarch 26, 2018NCT00702117Hospital Clinic of BarcelonaAtrial Fibrillation|Tachycardia, Ventricular|Brugada SyndromeJune 2008Phase 4 |
| Molecular Weight | 326.43 |
| Formula | C??H??N?O? |
| CAS No. | 4360-12-7 |
| 中文名称 | 阿马灵；阿义马林；西萝芙木碱 |
| SMILES | CN1C2=CC=CC=C2[C@@]34[C@]1([H])[C@@](C[C@H]5[C@H](CC)[C@H]6O)([H])[N@]6[C@]([H])([C@H]5[C@H]4O)C3 |
| Shipping | Room temperature in continental US; may vary elsewhere. |
| Storage | Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 month |
| Solvent & Solubility | In Vitro: DMSO : ≥ 100 mg/mL (306.34 mM) * "≥" means soluble, but saturation unknown. Preparing ConcentrationSolventMass1 mg5 mg10 mg1 mM3.0634 mL15.3172 mL30.6344 mL5 mM0.6127 mL3.0634 mL6.1269 mL10 mM0.3063 mL1.5317 mL3.0634 mL * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式 选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂： ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
*以上所有助溶剂都可在 MCE 网站选购。 |
| References |
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