HCV helicase^[1]

Tris(4-aminophenyl)methane (Compound 8) shows weak HCV helicase inhibition (30% inhibition at 100 μM)^[1] . To preserve RNA in a biological sample for analysis, the sample is incubated with an RNA preservative capable of precipitating RNA in an aqueous solution, such as a triphenylmethane dye (e.g., methyl green, crystal violet, pararosaniline, or Tris(4-aminophenyl)methane), cresyl violet, or cobalt ions. RNA preservation may be used in an immunostaining assay and other histochemical methods^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

289.37

C??H??N?

548-61-8

NC1=CC=C(C(C2=CC=C(N)C=C2)C3=CC=C(N)C=C3)C=C1

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Chen CS, et al. Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virushelicase. J Med Chem. 2009 May 14;52(9):2716-23.