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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | CS-108166A |
| 用途 | 标准品 |
| 包装规格 | |
| 纯度 | 99%% |
| CAS编号 | 223769-64-0 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。CSdroxystilbamidine bis(methanesulfonate) 是一种能够结合 DNA 和 RNA 的染料， 也被发现是细胞核糖核酸酶的强效抑制剂。
| Description | Hydroxystilbamidine bis(methanesulfonate), a dye capable of binding to both DNA and RNA, has been found to be a powerful inhibitor of cellular ribonucleases. |
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| In Vitro | It is found that the trypanocidal dye Hydroxystilbamidine bis(methanesulfonate) permits the recovery of mRNA after polysome released with Nonidet P-40 (NP-40). Sucrose gradient analysis of detergent-lysed postnuclear supernates is used to analyze the size distribution of NP-40-released polysomes. The heparin gradient shows some polyribosomes, whereas the Hydroxystilbamidine bis(methanesulfonate) gradient shows a remarkably large peak of very heavy polyribosomes. This peak is obtained reproducibly if Hydroxystilbamidine bis(methanesulfonate) is present before the addition of NP-40[1] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| In Vivo | Hydroxystilbamidine bis(methanesulfonate) is an effective suppressor of the plaque-forming cell (PFC) response when given before sheep erythrocytes (SRBC) stimulation. Hydroxystilbamidine bis(methanesulfonate) depresses the plaque response of the treated mice. Fewer PFC are observed in Hydroxystilbamidine bis(methanesulfonate)-treated mice throughout the experiment, but the level of suppression decreases with time. By day 14, the number of PFC observed in both the Hydroxystilbamidine bis(methanesulfonate) treated mice and the control group is essentially at the background level[2] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Molecular Weight | 472.54 |
| Formula | C??H??N?O?S? |
| CAS No. | 223769-64-0 |
| SMILES | NC(C1=CC=C(/C=C/C2=C(O)C=C(C(N)=N)C=C2)C=C1)=N.OS(=O)(C)=O.OS(=O)(C)=O |
| Shipping | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| References |
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