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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | CS-P1416A |
| 用途 | 分析检测 |
| 包装规格 | 1mg |
| 纯度 | 99%% |
| CAS编号 | |
| 是否进口 | 否 |
Foxy-5 是一种缺乏硫酸肝素结合域 WNT5A 模拟肽，具有抗转移作用。Foxy-5 在不影响 β-连环蛋白激活的情况下触发细胞溶质游离钙信号传导，并损害上皮癌细胞的迁移和侵袭。
| Description | Foxy-5 TFA, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 TFA triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 TFA effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model[1] [2] [3] [4] . |
|---|---|
| IC50 & Target | WNT5A[1] |
| In Vivo | Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model[1] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Clinical Trial | NCT NumberSponsorConditionStart DatePhaseNCT02655952WntResearch ABMetastatic Breast Cancer|Metastatic Colon Cancer|Metastatic Prostate CancerApril 2016Phase 1NCT02020291WntResearch ABMetastatic Breast Cancer|Colorectal Cancer|Prostate CancerJune 2013Phase 1NCT03883802WntResearch AB|SMS-Oncology BV|SAGA diagnostics AB|Unilabs A+S|BioVica AB|Catalan Institute of OncologyColon CancerApril 12, 2019Phase 2 |
| Molecular Weight | 808.80 |
| Formula | C??H??F?N?O??S? |
| Sequence | Met-Asp-Gly-Cys-Glu-Leu |
| Sequence Shortening | MDGCEL |
| Shipping | Room temperature in continental US; may vary elsewhere. |
| Storage | Powder-80°C2 years-20°C1 yearIn solvent-80°C6 months-20°C1 month |
| Solvent & Solubility | In Vitro: H2O : 20 mg/mL (24.73 mM; Need ultrasonic) Preparing ConcentrationSolventMass1 mg5 mg10 mg1 mM1.2364 mL6.1820 mL12.3640 mL5 mM0.2473 mL1.2364 mL2.4728 mL10 mM0.1236 mL0.6182 mL1.2364 mL * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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