Amylin, Calcitonin receptor^[1] .

Oral Calcitonin salmon treatment dose-dependently attenuates fasting and non-fasted hyperglycaemia during the intervention period. At the end of the study period, oral Calcitonin salmon treatment by dose decreases diabetic hyperglycaemia by ~9 mM and reduces HbA1c levels by 1.7%. Furthermore, a pronounced reduction in glucose excursions is dose-dependently observed for oral Calcitonin salmon treatment during oral glucose tolerance test. In addition, oral Calcitonin salmon treatment sustains hyperinsulinaemia and attenuates hyperglucagonaemia and hypersecretion of total glucagon-like peptide-1 predominantly in the basal state. Lastly, oral Calcitonin salmon treatment dose-dependently improves pancreatic beta-cell function and beta-cell area at study end^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NCT NumberSponsorConditionStart DatePhaseNCT00542984Eli Lilly and CompanyOsteoporosis, PostmenopausalAugust 2003Phase 3NCT00372099Rene Rizzoli|University Hospital, GenevaPostmenopauseJanuary 2007Phase 3NCT00704847Nordic Bioscience A+S|NovartisOsteoarthritisJune 2008Phase 3

3431.85

C???H???N??O??S?

47931-85-1

Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 (Disulfide bridge: Cys1-Cys7)

CSNLSTCVLGKLSQELHKLQTYPRTNTGSGTP-NH2 (Disulfide bridge: Cys1-Cys7)

降钙素 (鲑鱼)

Room temperature in continental US; may vary elsewhere.

Powder-80°C2 years-20°C1 yearIn solvent-80°C6 months-20°C1 month

In Vitro: 

H₂O : 100 mg/mL (29.14 mM; Need ultrasonic)

Preparing
Stock Solutions

ConcentrationSolventMass1 mg5 mg10 mg1 mM0.2914 mL1.4569 mL2.9139 mL5 mM0.0583 mL0.2914 mL0.5828 mL10 mM0.0291 mL0.1457 mL0.2914 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

• [1]. Feigh M, et al. Oral salmon calcitonin attenuates hyperglycaemia and preserves pancreatic beta-cell area and function in Zucker diabetic fatty rats. Br J Pharmacol. 2012 Sep;167(1):151-63.