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L-Asparaginase
  • 品牌:Chemstan
  • 产地:中国
  • 货号:CS-P1923
  • cas:9015-68-3
  • 价格: ¥500/支
  • 发布日期: 2020-04-27
  • 更新日期: 2025-09-19
产品详请
产地 中国
品牌 Chemstan
货号 CS-P1923
用途 分析检测
包装规格 100mg
纯度 99%%
CAS编号
是否进口
Description

L-Asparaginase (L-ASNase), a hydrolase that catalyzes the conversion of L-asparagine, used in acute lymphoblastic leukemia treatment. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis[1] .

Clinical Trial

NCT NumberSponsorConditionStart DatePhaseNCT00526175PETHEMA FoundationAcute Lymphoblastic LeukemiaJune 2001Phase 4NCT01358253Ruijin HospitalAcute Lymphoblastic LeukemiaDecember 2010Phase 4NCT00098839Children′s Oncology Group|National Cancer Institute (NCI)Recurrent Childhood Acute Lymphoblastic LeukemiaFebruary 2005Phase 1|Phase 2

CAS No.

9015-68-3

中文名称

L-天门冬酰胺酶

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Protect from light

Powder-80°C2 years-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro: 

0.1 M HCL : 50 mg/mL (ultrasonic and adjust pH to 3 with HCl)

H2O : < 0.1 mg/mL (insoluble)

References
  • [1]. Piatkowska-Jakubas B, et al. Use of L-asparaginase in acute lymphoblastic leukemia: recommendations of the Polish Adult Leukemia Group. Pol Arch Med Wewn. 2008 Nov;118(11):664-9.


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