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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | CS-P1674A |
| 用途 | 分析检测 |
| 包装规格 | 5mg |
| 纯度 | 99%% |
| CAS编号 | |
| 是否进口 | 否 |
| Description | Murepavadin (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic for the treatment of bacterial infections caused by Pseudomonas aeruginosa. Murepavadin (TFA) targets the lipopolysaccharide transport portin D [1] . |
|---|---|
| IC50 & Target | P. aeruginosa[1] . |
| Clinical Trial | NCT NumberSponsorConditionStart DatePhaseNCT03582007Polyphor Ltd.PneumoniaOctober 22, 2018Phase 3NCT02897869Polyphor Ltd.HealthyApril 2016Phase 1NCT02096328Polyphor Ltd.Ventilator Associated Pneumonia|Lower Respiratory InfectionOctober 2013Phase 2 |
| Molecular Weight | 1667.83 |
| Formula | C??H???N??O??.C?HF?O? |
| Sequence Shortening | Cyclo(AS-{d-Pro}-PTWI-{Dab}-{Orn}-{d-Dab}-{Dab}-W-{Dab}-{Dab}) |
| Shipping | Room temperature in continental US; may vary elsewhere. |
| Storage | Powder-80°C2 years-20°C1 yearIn solvent-80°C6 months-20°C1 month |
| Solvent & Solubility | In Vitro: H2O Peptide Solubility and Storage Guidelines: 1. Calculate the length of the peptide. 2. Calculate the overall charge of the entire peptide according to the following table: ContentsAssign valueAcidic amino acidAsp (D), Glu (E), and the C-terminal -COOH.-1Basic amino acidArg (R), Lys (K), His (H), and the N-terminal -NH2+1Neutral amino acidGly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)0 3. Recommended solution: Overall charge of peptideDetailsNegative (<0)1. Try to dissolve the peptide in water first.2. If water fails, add NH4OH (<50 μL).3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.Positive (>0)1. Try to dissolve the peptide in water first.2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.Zero (=0)1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. |
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